William E Van Nostrand Selected Research

Cerebral Amyloid Angiopathy (Congophilic Angiopathy)

10/2022	Normal cerebrospinal fluid concentrations of PDGFRβ in patients with cerebral amyloid angiopathy and Alzheimer's disease.
1/2022	Emergent White Matter Degeneration in the rTg-DI Rat Model of Cerebral Amyloid Angiopathy Exhibits Unique Proteomic Changes.
1/2022	Impact of Non-pharmacological Chronic Hypertension on a Transgenic Rat Model of Cerebral Amyloid Angiopathy.
1/2022	Elevated expression of urokinase plasminogen activator in rodent models and patients with cerebral amyloid angiopathy.
1/2022	Insights into Cerebral Amyloid Angiopathy Type 1 and Type 2 from Comparisons of the Fibrillar Assembly and Stability of the Aβ40-Iowa and Aβ40-Dutch Peptides.
11/2021	Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aβ40 fibrils.
10/2021	Distinct brain regional proteome changes in the rTg-DI rat model of cerebral amyloid angiopathy.
1/2021	Anti-Parallel β-Hairpin Structure in Soluble Aβ Oligomers of Aβ40-Dutch and Aβ40-Iowa.
12/2020	The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer's disease.
3/2020	Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1.

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William E Van Nostrand Research Topics

Disease

55	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 09/2002
33	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 10/2022 - 11/2002
17	Amyloid Plaque 11/2021 - 09/2002
13	Neuroinflammatory Diseases 01/2022 - 07/2005
11	Dementia (Dementias) 01/2022 - 07/2005
10	Cognitive Dysfunction 10/2022 - 03/2007
5	Cerebral Hemorrhage 10/2021 - 12/2005
5	Intracranial Thrombosis (Cerebral Thrombosis) 07/2017 - 12/2005
4	Hemorrhage 01/2016 - 01/2006
3	Thrombosis (Thrombus) 03/2016 - 09/2007
2	Cerebral Small Vessel Diseases 01/2022 - 10/2021
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 02/2015
2	Vascular System Injuries 04/2009 - 09/2007
2	Hematoma 04/2009 - 09/2007
2	Familial Cerebral Amyloid Angiopathy 03/2007 - 07/2005
2	Amyloidosis 01/2006 - 08/2004
1	Megalencephalic leukoencephalopathy with subcortical cysts 01/2022
1	Hypertension (High Blood Pressure) 01/2022
1	Cerebral Infarction 10/2021
1	Ischemia 01/2016
1	Hyperemia 06/2014
1	Hypercapnia 06/2014
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 07/2012
1	Platelet Glycoprotein IV Deficiency 03/2011
1	Amyloid angiopathy 10/2010
1	Inflammation (Inflammations) 08/2006
1	Pathologic Processes 08/2006
1	Hemorrhagic Stroke 01/2006

Drug/Important Bio-Agent (IBA)

43	Amyloid (Amyloid Fibrils)IBA 01/2022 - 07/2005
29	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2004
23	Amyloid beta-PeptidesIBA 12/2020 - 09/2002
14	Peptides (Polypeptides)IBA 01/2022 - 08/2008
5	Apolipoproteins E (ApoE)IBA 12/2020 - 04/2005
5	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 04/2009 - 11/2002
4	ApolipoproteinsIBA 01/2012 - 04/2005
3	Biomarkers (Surrogate Marker)IBA 10/2022 - 01/2006
3	CopperIBA 01/2020 - 04/2013
3	Peptide Hydrolases (Proteases)FDA Link 07/2017 - 12/2005
3	Myelin Basic ProteinIBA 11/2013 - 03/2007
3	Nitric Oxide Synthase (NO Synthase)IBA 10/2010 - 02/2008
2	AntibodiesIBA 11/2010 - 12/2007
2	Matrix Metalloproteinase 2 (Gelatinase A)IBA 02/2010 - 08/2006
2	Hemoglobins (Hemoglobin)IBA 04/2009 - 09/2007
2	Pharmaceutical PreparationsIBA 03/2007 - 08/2006
2	CytokinesIBA 09/2006 - 08/2005
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2022
1	Dihydrotachysterol (AT 10)IBA 01/2022
1	Cystatin CIBA 01/2022
1	Plasminogen Activators (Plasminogen Activator)IBA 01/2022
1	Annexin A3IBA 01/2022
1	Annexin A5IBA 01/2022
1	ProteomeIBA 10/2021
1	Amyloidogenic ProteinsIBA 01/2020
1	ZincIBA 01/2020
1	Amino Acids FDA Link 01/2019
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2019
1	Biotin (Vitamin H)FDA Link 06/2014
1	Staphylococcal Protein A (Protein A)IBA 06/2014
1	PorphyrinsIBA 06/2014
1	Adenosine (Adenocard)FDA LinkGeneric 06/2014
1	Endothelium-Dependent Relaxing Factors (Endothelium Derived Relaxing Factor)IBA 06/2014
1	Free Radical ScavengersIBA 06/2014
1	MetalsIBA 04/2013
1	IonsIBA 04/2013
1	IronIBA 04/2013
1	tau Proteins (tau Protein)IBA 10/2010
1	Matrix Metalloproteinase InhibitorsIBA 02/2010
1	N- (2(R)- 2- (hydroxamidocarbonylmethyl)- 4- methylpentanoyl)- L- tryptophan methylamideIBA 02/2010
1	Tissue Inhibitor of MetalloproteinasesIBA 02/2010
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 02/2010
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 04/2009
1	AnticoagulantsIBA 04/2009
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2008
1	thioflavin TIBA 08/2008
1	Apolipoprotein E3IBA 05/2008
1	Apolipoprotein E4IBA 05/2008
1	Minocycline (Cyclops)FDA LinkGeneric 03/2007
1	Messenger RNA (mRNA)IBA 09/2006
1	Ibuprofen (Motrin)FDA LinkGeneric 08/2006
1	Indomethacin (Indometacin)FDA LinkGeneric 08/2006
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 08/2006
1	Actins (F Actin)IBA 08/2006
1	Interleukin-6 (Interleukin 6)IBA 08/2006
1	GelatinIBA 08/2006
1	Dexamethasone (Maxidex)FDA LinkGeneric 08/2006
1	Interleukin-1beta (Interleukin 1 beta)IBA 08/2005
1	LDL Receptors (LDL Receptor)IBA 08/2004
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2004

Therapy/Procedure

2	Immunotherapy 06/2009 - 08/2008
1	Lasers (Laser) 11/2021
1	Therapeutics 01/2018
1	Cognitive Training 01/2017